Today, environmental pollution, intense sun exposure, stress, sleep irregularities, and the biological aging process silently weaken our skin’s outermost shield, the protective barrier. A skin with a weakened barrier rapidly loses its moisture, becomes vulnerable to external factors, dulls, and begins to show early signs of wrinkles. Often, expensive creams or serums applied from the outside fall short in repairing this biological wear and tear in the lower layers of the skin. Because true rejuvenation and renewal are only possible when the skin repairs itself at the cellular level.
This is exactly where Rejuran Treatment (Polynucleotide – PN), which has made a great impact in the field of medical aesthetics worldwide and is described as “cellular healing,” comes into play. Spreading all over the world, especially from South Korea, this innovative approach that structures the skin from the inside has become one of the primary choices for those who want to naturally improve their skin quality in Istanbul as well.
Located in the center of the transportation networks of the Anatolian Side of Istanbul, at Kartal Bumerang Residence; we welcome our clients from many districts such as Pendik, Maltepe, Ataşehir, Kadıköy, and Tuzla, and meticulously apply Rejuran protocols that activate the skin’s biological healing potential. In this comprehensive guide, you can find all the details you are wondering about, from what Rejuran treatment is and its mechanism of action to session intervals, physician selection, and pricing criteria.
What is Rejuran? (Polynucleotide and Cellular Repair)
Rejuran is a skin bioregeneration (restructuring) injection consisting of Polynucleotide (PN) chains, the main active ingredient of which is obtained by purifying wild salmon DNA. Having over 98% biological compatibility with human DNA, these special molecules are accepted by the body as a completely natural building block when administered to the skin.
While classic hyaluronic acid mesotherapies only provide instant moisture to the skin or traditional fillers add volume (swelling) to specific areas of the face; Rejuran works with a completely different philosophy. Rejuran is not a dermal filler; it does not change the anatomical lines of the face or freeze facial expressions. Its main purpose is to repair damaged skin tissue, fibroblast cells, and collagen fibers at the cellular level, restoring the skin to its healthy, elastic, and resilient form from years ago.
What Does Rejuran Do? Primary Benefits for the Skin
When Rejuran is injected into the dermis layer of the skin, it essentially establishes a biological repair site. The main benefits this treatment provides to the skin are:
- Strengthens the Skin Barrier: It thickens and builds resilience in an overly sensitized, thinned skin barrier that reacts to external factors.
- Triggers Collagen and Elastin Production: By stimulating fibroblasts, it enables the skin to produce its own youth proteins; this increases skin firmness and elasticity.
- Improves Large Pores and Skin Texture: As the loss of elasticity under the tissue is recovered, gravity-enlarged pores tighten, and the skin surface becomes smoother.
- Softens Fine Lines and Wrinkles: It alleviates fine wrinkles, especially around the eyes, lips, and neck, by filling them from the inside.
- Regulates Sebum and Moisture Balance: It creates a balanced, healthy, and moisture-saturated skin flora by managing excessive oiliness or extreme dryness.
- Soothes Acne Scars and Redness: Thanks to its cellular regeneration effect, it helps soften scars and lighten chronic redness on the skin.
- Provides a Natural and Lasting Glow: It eliminates a dull and pale appearance by increasing the skin’s light-reflecting capacity.
Who Can Have Rejuran Treatment?
Rejuran is suitable for a wide audience, regardless of gender, who wants to invest in their skin’s health and achieve natural renewal:
- Those with a weakened skin barrier, constantly experiencing dryness and flaking.
- Those whose fine wrinkles are becoming prominent and who feel a loss of elasticity.
- Those with acne scars, enlarged pores, or rough skin surfaces.
- Those whose skin is worn out after laser, chemical peeling, or sunburn and needs repair.
- Anyone who wants to simply reveal “their skin’s most vigorous and healthy state” without adding artificial volume or changing their facial expression.
Who Is It Not Recommended For?
Although Rejuran has an extremely high safety profile and biocompatibility, it is not recommended in some cases due to medical safety protocols:
- Individuals known to have a severe, anaphylactic allergy to salmon or seafood.
- Women during pregnancy and lactation.
- Those with an active skin infection, herpes, or open wound in the application area.
- Individuals with active immune system diseases or those undergoing cancer treatment.
The Treatment Process: How is Rejuran Applied?
In our clinic, the Rejuran application is performed with sensitive medical standards to maximize our clients’ comfort:
- Skin Analysis and Consultation: Our physician evaluates your skin’s barrier status, elasticity, and needs to determine a personalized injection map.
- Comfortable Anesthesia: After the skin is gently cleansed, medical-grade strong local anesthetic creams are applied to minimize the stinging sensation during the procedure, and a waiting period of about 20-30 minutes is observed.
- Micro-Injection Stage: Using very fine-tipped special mesotherapy needles, micro-papules (small bumps) are injected into the dermis layer of the skin at 1-2 cm intervals. The product is placed directly into the layer where the damaged tissue lies.
- Soothing Care: Once the injection is complete, the procedure concludes with the application of special masks and serums that soothe the skin. The application takes an average of 30-45 minutes.
Things to Consider Before and After Treatment
To increase the success of the procedure and minimize potential temporary side effects, certain rules must be observed:
Before the Treatment:
- A few days before the procedure, limiting blood-thinning medications and heavy alcohol consumption in consultation with your physician reduces the risk of bruising.
- It is recommended not to wear heavy makeup on the day of the application.
After the Treatment:
- Small bumps (papules) formed at the injection points indicate that the product has settled under the tissue and usually absorb entirely on their own within 24 to 48 hours. These bumps should absolutely not be squeezed or rubbed.
- The face should not be washed, makeup should not be applied, and the skin should not be touched for the first 24 hours.
- Hot baths, saunas, Turkish baths, solariums, and intense exercise should be avoided for the first 3 days.
- The skin must be meticulously protected from the sun, and high-factor broad-spectrum sunscreens should be used regularly.
How Many Sessions Are Applied and How Long Does the Effect Last?
Rejuran is not a one-time superficial procedure but a cumulative (building up) biological repair process:
- Session Protocol: For the most effective and long-term results, an initial cure of 3 or 4 sessions at 2 to 3-week intervals is generally recommended.
- Time of Effect: Softening and moisture increase in the skin begin within 1-2 weeks after the first session. The main collagen restructuring and barrier repair reach their maximum level after the 2nd and 3rd sessions.
- Duration of Permanence: The healthy and fresh skin structure achieved after the cure is completed is maintained for an average of 12 to 18 months. Single-session reminder applications once or twice a year help extend the youthful quality of the skin over many years.
The Importance of Choosing Doctors and Clinics for Rejuran Treatment
The abundance of options in the field of medical aesthetics in metropolises like Istanbul further increases the importance of choosing a physician. The secret of success in Rejuran application is not only the quality of the product but also the injection of that product into the correct depth of the skin (the exact dermis layer) and with the right technique.
The following elements should be considered when choosing a physician:
- The practitioner must be a medical doctor who has mastered human facial anatomy, skin layers, and medical aesthetic principles.
- It is of vital importance that the Rejuran vials used are original, approved by the Ministry of Health, and stored in accordance with cold chain rules.
- Clinics that treat each patient’s skin structure as a separate case and offer personalized protocols away from commercial concerns—similar to our medical approach derived from the GATA discipline—should be preferred.
How Are Rejuran Istanbul Prices Determined?
It is not the right approach to offer a fixed and standard package price in medical aesthetic applications. Istanbul Rejuran prices vary depending entirely on the following fundamental factors determined by the person’s skin analysis:
- Amount of Product Used (Number of Vials/Syringes): Depending on the skin’s needs, using 2 ml per session or 4 ml for larger areas directly affects the cost.
- Application Area: Whether the procedure will be applied only to the entire face or in combination with the neck, décolleté, or eye contour determines the budget.
- Number of Sessions: Whether a 3-session protocol or an advanced 4-session cure will be applied to the person shapes the total cost.
- Originality of the Product: Only barcoded and original Rejuran products with international standards are used in our clinic.
The healthiest pricing and treatment planning are established after a face-to-face preliminary examination and detailed skin analysis in our clinic.
Frequently Asked Questions (FAQ)
- When do the bumps (papules) that form after the procedure disappear? The tiny bumps seen at the injection points are completely natural and show that the product has settled in the correct layer. Depending on the skin structure and lymphatic circulation, they usually dissolve on their own within 24 to 48 hours and integrate with the tissue.
- What is the difference between Rejuran and the Youth Vaccine or Standard Mesotherapy? Standard mesotherapies mostly contain hyaluronic acid and vitamins; they moisturize the skin but do not provide repair at the genetic and cellular levels. Rejuran, on the other hand, helps repair damaged cell DNA and allows the tissue to rebuild itself thanks to its Polynucleotide chains.
- Can Rejuran be applied for wrinkles around the eyes? Yes. Thinner formulations developed specifically for the eye contour area from the Rejuran family (Rejuran I) are among the safest and most effective solutions for crow’s feet, under-eye bagging tendencies, and fine skin wrinkles around the eyes.
- Is it safe to have Rejuran in the summer months? Since Rejuran is not a laser or chemical peeling procedure, it does not make the skin overly sensitive to the sun. It can be safely applied in all four seasons; in fact, it is frequently preferred during the summer months to protect the skin barrier against the damaging effects of the sun.
Rejuvenate While Preserving Your Naturalness
Seeing a tired, lifeless skin with a collapsed barrier when you look in the mirror is not your destiny. Restoring your skin’s own health and glow without disrupting the natural architecture of your face and without resorting to an artificial look is the most valuable opportunity modern medicine offers.
To start your skin’s biological renewal journey, create your personalized Rejuran treatment plan, and proceed safely under the supervision of a specialist physician, we invite you to meet Dr. Mustafa Eray Erkek and our experienced clinical team at our center in Kartal Bumerang Residence. Remember; the most beautiful aesthetic touch is the one that goes unnoticed but adds perfect health to your skin.
